Symbol
Name
ID

Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
MGI:2157910

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Spasticity	Diffuse swelling of cerebral white matter	Diffuse spongiform leukoencephalopathy	Megalencephaly	Ataxia	Intellectual disability, mild	Motor delay	Seizure
Disease(s) Associated with MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1

Mouse Phenotypes

cerebral edema

increased brain weight

increased brain size

abnormal brain white matter morphology

abnormal corpus callosum morphology

abnormal cerebellum morphology

brain vacuoles

abnormal astrocyte morphology

astrocytosis

abnormal myelin sheath morphology

abnormal glial cell physiology

abnormal astrocyte physiology

abnormal oligodendrocyte physiology

Availability

Mouse Genotype

Mlc1^{tm1.1(KOMP)Vlcg}/Mlc1^{tm1.1(KOMP)Vlcg}

Mlc1^tm1.1Rhn/Mlc1^tm1.1Rhn
Tg(Mlc1-tTA)2Rhn/0

Mlc1^tm1.1Vdk/Mlc1^tm1.1Vdk

Mlc1^tm1.2Nune/Mlc1^tm1.2Nune

Mlc1^tm1Rhn/Mlc1^tm1Rhn

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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